Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment.

ABSTRACT:

Background

Uterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood.

Methods

Expression profiling data were used to determine the possibility and optimal number of ULMS molecular subtypes. Next, clinicopathological characters and molecular pathways were analyzed in each subtype to prospect the clinical applications and progression mechanisms of ULMS.

Results

Two distinct molecular subtypes of ULMS were defined based on different gene expression signatures. Subtype I ULMS recapitulated low-grade ULMS, the gene expression pattern of which resembled normal smooth muscle cells, characterized by overexpression of smooth muscle function genes such as LMOD1, SLMAP, MYLK, MYH11. In

SUBMITTER: An Y 

PROVIDER: S-EPMC5594508 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature