A new solvate of epalerstat, a drug for diabetic neuropathy.

ABSTRACT: Epalerstat {systematic name: (5Z)-5-[(2E)-2-methyl-3-phenyl-prop-2-en-1-yl-idene]-4-oxo-2-sulfanyl-idene-1,3-thia-zolidine-3-acetic acid} crystallized as an acetone monosolvate, C₁₅H₁₃NO₃S₂·C₃H₆O. In the epalerstat mol-ecule, the methyl-propyl-enediene moiety is inclined to the phenyl ring and the five-membered rhodamine ring by 21.4 (4) and 4.7 (4)°, respectively. In addition, the acetic acid moiety is found to be almost normal to the rhodamine ring, making a dihedral angle of 85.1 (2)°. In the crystal, a pair of O-H⋯O hydrogen bonds between the carb-oxy-lic acid groups of epalerstat mol-ecules form inversion dimers with an R₂²(8) loop. The dimers are linked by pairs of C-H⋯O hydro

SUBMITTER: Putra OD 

PROVIDER: S-EPMC5598862 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature