Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin.

ABSTRACT: Osteosarcoma is the most common bone cancer in dogs and people. In order to improve clinical outcomes, it is necessary to identify proteins that are differentially expressed by metastatic cells. Membrane bound proteins are responsible for multiple pro-metastatic functions. Therefore characterizing the differential expression of membranous proteins between metastatic and non-metastatic clonal variants will allow the discovery of druggable targets and consequently improve treatment methodology. The objective of this investigation was to systemically identify the membrane-associated proteomics of metastatic and non-metastatic variants of human and canine origin. Two clonal variants of divergent in vivo metastatic potential from human and canine origins were used. The plasma membranes were iso

SUBMITTER: Roy J 

PROVIDER: S-EPMC5598957 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature