Precise Protein Photolithography (P³): High Performance Biopatterning Using Silk Fibroin Light Chain as the Resist.

ABSTRACT: Precise patterning of biomaterials has widespread applications, including drug release, degradable implants, tissue engineering, and regenerative medicine. Patterning of protein-based microstructures using UV-photolithography has been demonstrated using protein as the resist material. The Achilles heel of existing protein-based biophotoresists is the inevitable wide molecular weight distribution during the protein extraction/regeneration process, hindering their practical uses in the semiconductor industry where reliability and repeatability are paramount. A wafer-scale high resolution patterning of bio-microstructures using well-defined silk fibroin light chain as the resist material is presented showing unprecedent performances. The lithographic and etching performance of silk fibroin li

SUBMITTER: Liu W 

PROVIDER: S-EPMC5604371 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature