Alzheimer's disease genetic risk variants beyond APOE ε4 predict mortality.

ABSTRACT:

Introduction

We hypothesized that, like apolipoprotein E (APOE), other late-onset Alzheimer's disease (LOAD) genetic susceptibility loci predict mortality.

Methods

We used a weighted genetic risk score (GRS) from 21 non-APOE LOAD risk variants to predict survival in the Adult Changes in Thought and the Health and Retirement Studies. We meta-analyzed hazard ratios and examined models adjusted for cognitive performance or limited to participants with dementia. For replication, we assessed the GRS-longevity association in the Cohorts for Heart and Aging Research in Genomic Epidemiology, comparing cases surviving to age ≥90 years with controls who died between ages 55 and 80 years.

Results

Higher GRS predicted mortality (hazard ratio = 1.05; 95% confidence i

SUBMITTER: Mez J 

PROVIDER: S-EPMC5604953 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature