Cardioprotective effects of 5-hydroxymethylfurfural mediated by inhibition of L-type Ca²⁺ currents.

ABSTRACT:

Background and purpose

The antioxidant 5-hydroxymethylfurfural (5-HMF) exerts documented beneficial effects in several experimental pathologies and is currently tested as an antisickling drug in clinical trials. In the present study, we examined the cardiovascular effects of 5-HMF and elucidated the mode of action of the drug.

Experimental approach

The cardiovascular effects of 5-HMF were studied with pre-contracted porcine coronary arteries and rat isolated normoxic-perfused hearts. Isolated hearts subjected to ischaemia/reperfusion (I/R) injury were used to test for potential cardioprotective effects of the drug. The effects of 5-HMF on action potential and L-type Ca²⁺ current (I_Ca,L ) were studied by patch-clamping guinea pig isolated ventricular car

SUBMITTER: Wolkart G 

PROVIDER: S-EPMC5610158 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature