Radiofluorination of a NHC-PF₅ adduct: toward new probes for ¹⁸F PET imaging.

ABSTRACT: The radiofluorination of N-heterocyclic carbene (NHC) phosphorus(v) fluoride adducts has been investigated. The results show that the IMe-PF₅ derivative (IMe = 1,3-dimethylimidazol-2-ylidene) undergoes a Lewis acid promoted ¹⁸F-¹⁹F isotopic exchange. The resulting radiofluorinated probe is remarkably resistant to hydrolysis both in vitro as well as in vivo.

SUBMITTER: Vabre B 

PROVIDER: S-EPMC5615223 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature