In Quest for Improved Drugs against Diabetes: The Added Value of X-ray Powder Diffraction Methods.

ABSTRACT: Human insulin (HI) is a well-characterized natural hormone which regulates glycose levels into the blood-stream and is widely used for diabetes treatment. Numerous studies have manifested that despite significant efforts devoted to structural characterization of this molecule and its complexes with organic compounds (ligands), there is still a rich diagram of phase transitions and novel crystalline forms to be discovered. Towards the improvement of drug delivery, identification of new insulin polymorphs from polycrystalline samples, simulating the commercially available drugs, is feasible today via macromolecular X-ray powder diffraction (XRPD). This approach has been developed, and is considered as a respectable method, which can be employed in biosciences for various purposes, such as ob

SUBMITTER: Karavassili F 

PROVIDER: S-EPMC5618244 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature