Synthesis, Characterization, and Evaluation of Cytotoxic Effects of Novel Hybrid Steroidal Heterocycles as PEG Based Nanoparticles
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ABSTRACT:
SUBMITTER: Abd Elhalim MM
PROVIDER: S-EPMC5648402 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Synthesis, Characterization, and Evaluation of Cytotoxic Effects of Novel Hybrid Steroidal Heterocycles as PEG Based Nanoparticles
Abd Elhalim Mervat M MM Ismail Nasser S M NSM M Yahya Shaymaa M SM Omar Yasmin Y YY Abd Rabou Ahmed A AA Lasheen Deena S DS Zawrah Mahmoud F MF Elmegeed Gamal A GA
Asian Pacific journal of cancer prevention : APJCP 20170727 7
Anticancer agents featuring hybrid molecules can improve effectiveness and diminish drug resistance. The current study aimed to introduce newly synthesized heterocyclic steroids of promising anticancer effects loaded in polyethylene glycol (PEG)•based nanoparticles form. Several heterocyclic steroids (1-9) were synthesized via multicomponent reactions (MCRs) and confirmed via the analytical and spectral data. Compounds 1, 2, 3, 4, 5, 6, 7 and 9, were investigated individually in their free and P ...[more]
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