Epstein-Barr virus, cytomegalovirus, and multiple sclerosis susceptibility: A multiethnic study.

ABSTRACT:

Objective

To determine whether Epstein-Barr virus (EBV) or cytomegalovirus (CMV) seropositivity is associated with multiple sclerosis (MS) in blacks and Hispanics and to what extent measures of the hygiene hypothesis or breastfeeding could explain these findings. EBV and CMV have been associated with MS risk in whites, and the timing and frequency of both viruses vary by factors implicated in the hygiene hypothesis.

Methods

Incident cases of MS or its precursor, clinically isolated syndrome (CIS), and matched controls (blacks, 111 cases/128 controls; Hispanics, 173/187; whites, 235/256) were recruited from the membership of Kaiser Permanente Southern California. Logistic regression models accounted for HLA-DRB1*1501 status, smoking, socioeconomic status, age, sex, gen

SUBMITTER: Langer-Gould A 

PROVIDER: S-EPMC5649756 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature