Chemical characterization of wound ointment (WO) and its effects on fracture repair: a rabbit model.

ABSTRACT:

Background

Wound ointment (WO), a kind of Chinese medicine, can significantly promote fracture healing. The study aimed at analyzing the chemical composition and the effects of WO on fracture of rabbits and tried to explore the corresponding molecular mechanism in cytokine.

Methods

The qualitative and quantitative analysis of WO was conducted by liquid chromatography-mass spectrometry (LC-MS). Fifty-four Zealand mature male rabbits were randomly divided into 3 groups: Control group, Yunnan Baiyao (YB) group and WO group. All the rabbits suffered a fracture of right radius and were then stabilized with an external fixator. Treated with different methods, fracture healing was observed. The bone specimens were subjected to radiograph, immunohistochemistry (IHC) analysis, hemato

SUBMITTER: Ou Z 

PROVIDER: S-EPMC5661936 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature