Human CD141⁺ Dendritic Cell and CD1c⁺ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo.

ABSTRACT: Human immune cell subsets develop in immunodeficient mice following reconstitution with human CD34⁺ hematopoietic stem cells. These "humanized" mice are useful models to study human immunology and human-tropic infections, autoimmunity, and cancer. However, some human immune cell subsets are unable to fully develop or acquire full functional capacity due to a lack of cross-reactivity of many growth factors and cytokines between species. Conventional dendritic cells (cDCs) in mice are categorized into cDC1, which mediate T helper (Th)1 and CD8⁺ T cell responses, and cDC2, which mediate Th2 and Th17 responses. The likely human equivalents are CD141⁺ DC and CD1c⁺ DC subsets for mouse cDC1 and cDC2, respectively, but the extent of any interspecies dif

SUBMITTER: Minoda Y 

PROVIDER: S-EPMC5670352 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature