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Genome-wide association study of prostate cancer-specific survival.

ABSTRACT: BACKGROUND:Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. METHODS:We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). RESULTS:We observed no significant association between genetic variants and prostate cancer survival. CONCLUSIONS:Common genetic variants with large impact on prostate cancer survival were not observed in this study. IMPACT:Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

SUBMITTER: Szulkin R 

PROVIDER: S-EPMC5674990 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Genome-wide association study of prostate cancer-specific survival.

Szulkin Robert R   Karlsson Robert R   Whitington Thomas T   Aly Markus M   Gronberg Henrik H   Eeles Rosalind A RA   Easton Douglas F DF   Kote-Jarai Zsofia Z   Al Olama Ali Amin AA   Benlloch Sara S   Muir Kenneth K   Giles Graham G GG   Southey Melissa C MC   FitzGerald Liesel M LM   Henderson Brian E BE   Schumacher Fredrick R FR   Haiman Christopher A CA   Sipeky Csilla C   Tammela Teuvo L J TL   Nordestgaard Børge G BG   Key Timothy J TJ   Travis Ruth C RC   Neal David E DE   Donovan Jenny L JL   Hamdy Freddie C FC   Pharoah Paul D P PD   Pashayan Nora N   Khaw Kay-Tee KT   Stanford Janet L JL   Thibodeau Stephen N SN   McDonnell Shannon K SK   Schaid Daniel J DJ   Maier Christiane C   Vogel Walther W   Luedeke Manuel M   Herkommer Kathleen K   Kibel Adam S AS   Cybulski Cezary C   Lubiński Jan J   Kluźniak Wojciech W   Cannon-Albright Lisa L   Brenner Hermann H   Herrmann Volker V   Holleczek Bernd B   Park Jong Y JY   Sellers Thomas A TA   Lim Hui-Yi HY   Slavov Chavdar C   Kaneva Radka P RP   Mitev Vanio I VI   Spurdle Amanda A   Teixeira Manuel R MR   Paulo Paula P   Maia Sofia S   Pandha Hardev H   Michael Agnieszka A   Kierzek Andrzej A   Batra Jyotsna J   Batra Jyotsna J   Clements Judith A JA   Albanes Demetrius D   Andriole Gerald L GL   Berndt Sonja I SI   Chanock Stephen S   Gapstur Susan M SM   Giovannucci Edward L EL   Hunter David J DJ   Kraft Peter P   Le Marchand Loic L   Ma Jing J   Mondul Alison M AM   Penney Kathryn L KL   Stampfer Meir J MJ   Stevens Victoria L VL   Weinstein Stephanie J SJ   Trichopoulou Antonia A   Bueno-de-Mesquita Bas H BH   Tjønneland Anne A   Cox David G DG   Maehle Lovise L   Schleutker Johanna J   Lindström Sara S   Wiklund Fredrik F  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20150825 11

<h4>Background</h4>Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.<h4>Methods</h4>We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).<h4>Results</h4>W  ...[more]

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