Genome-wide association study of prostate cancer-specific survival.

ABSTRACT:

Background

Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical.

Methods

We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR).

Results

We observed no significant association between genetic variants and prostate cancer survival.

Conclusions

Common genetic variants with large impact on prostate cancer survival were not observed in this study.

Impact

Future studies should be designed for identification of rare variants w

SUBMITTER: Szulkin R 

PROVIDER: S-EPMC5674990 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature