Autologous Cell Seeding in Tracheal Tissue Engineering.

ABSTRACT:

Purpose of review

There is no consensus on the best technology to be employed for tracheal replacement. One particularly promising approach is based upon tissue engineering and involves applying autologous cells to transplantable scaffolds. Here, we present the reported pre-clinical and clinical data exploring the various options for achieving such seeding.

Recent findings

Various cell combinations, delivery strategies, and outcome measures are described. Mesenchymal stem cells (MSCs) are the most widely employed cell type in tracheal bioengineering. Airway epithelial cell luminal seeding is also widely employed, alone or in combination with other cell types. Combinations have thus far shown the greatest promise. Chondrocytes may improve mechanical outcomes in pre-clinical m

SUBMITTER: Maughan EF 

PROVIDER: S-EPMC5683058 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature