Ontology highlight
ABSTRACT:
SUBMITTER: Liang Z
PROVIDER: S-EPMC5696378 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171120 1
In human cells, DNA is hierarchically organized and assembled with histones and DNA-binding proteins in three dimensions. Chromatin interactions play important roles in genome architecture and gene regulation, including robustness in the developmental stages and flexibility during the cell cycle. Here we propose in situ Hi-C method named Bridge Linker-Hi-C (BL-Hi-C) for capturing structural and regulatory chromatin interactions by restriction enzyme targeting and two-step proximity ligation. Thi ...[more]