A liver-specific gene expression panel predicts the differentiation status of in vitro hepatocyte models.

ABSTRACT: Alternative cell sources, such as three-dimensional organoids and induced pluripotent stem cell-derived cells, might provide a potentially effective approach for both drug development applications and clinical transplantation. For example, the development of cell sources for liver cell-based therapy has been increasingly needed, and liver transplantation is performed for the treatment for patients with severe end-stage liver disease. Differentiated liver cells and three-dimensional organoids are expected to provide new cell sources for tissue models and revolutionary clinical therapies. However, conventional experimental methods confirming the expression levels of liver-specific lineage markers cannot provide complete information regarding the differentiation status or degree of similarity

SUBMITTER: Kim DS 

PROVIDER: S-EPMC5698781 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature