Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice.

ABSTRACT: Autoimmune lymphoproliferative syndrome (ALPS) is an incurable disease mainly caused by the defect of Fas-mediated apoptosis and characterized by nonmalignant autoimmune lymphoproliferation. Stabilized β-catenin could not only potentiate Fas-mediated T cell apoptosis via upregulating the expression of Fas on activated T cells, but also potentiate T cell apoptosis via intrinsic apoptotic pathway. In the present study, we introduced β-cat^Tg into lpr/lpr mice and aimed to explore the potential role of stabilized β-catenin (β-cat^Tg) in the development of ALPS-like phenotypes of lpr/lpr mice. We found that the total splenocyte cells and some compositions were slightly downregulated in β-cat^Tglpr</

SUBMITTER: Xu X 

PROVIDER: S-EPMC5700472 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature