A stepwise neuron model fitting procedure designed for recordings with high spatial resolution: Application to layer 5 pyramidal cells.

ABSTRACT:

Background

Recent progress in electrophysiological and optical methods for neuronal recordings provides vast amounts of high-resolution data. In parallel, the development of computer technology has allowed simulation of ever-larger neuronal circuits. A challenge in taking advantage of these developments is the construction of single-cell and network models in a way that faithfully reproduces neuronal biophysics with subcellular level of details while keeping the simulation costs at an acceptable level.

New method

In this work, we develop and apply an automated, stepwise method for fitting a neuron model to data with fine spatial resolution, such as that achievable with voltage sensitive dyes (VSDs) and Ca²⁺ imaging.

Result

We apply our method to simulated d

SUBMITTER: Maki-Marttunen T 

PROVIDER: S-EPMC5705475 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature