Organocatalytic asymmetric chlorinative dearomatization of naphthols.

ABSTRACT: An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.

SUBMITTER: Yin Q 

PROVIDER: S-EPMC5707459 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature