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A highly printable and biocompatible hydrogel composite for direct printing of soft and perfusable vasculature-like structures.

ABSTRACT: Vascularization is one major obstacle in bioprinting and tissue engineering. In order to create thick tissues or organs that can function like original body parts, the presence of a perfusable vascular system is essential. However, it is challenging to bioprint a hydrogel-based three-dimensional vasculature-like structure in a single step. In this paper, we report a new hydrogel-based composite that offers impressive printability, shape integrity, and biocompatibility for 3D bioprinting of a perfusable complex vasculature-like structure. The hydrogel composite can be used on a non-liquid platform and is printable at human body temperature. Moreover, the hydrogel composite supports both cell proliferation and cell differentiation. Our results represent a potentially new vascularization strategy for 3D bioprinting and tissue engineering.

SUBMITTER: Suntornnond R

PROVIDER: S-EPMC5714969 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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A highly printable and biocompatible hydrogel composite for direct printing of soft and perfusable vasculature-like structures.

Suntornnond Ratima R Tan Edgar Yong Sheng EYS An Jia J Chua Chee Kai CK

Scientific reports 20171204 1

Vascularization is one major obstacle in bioprinting and tissue engineering. In order to create thick tissues or organs that can function like original body parts, the presence of a perfusable vascular system is essential. However, it is challenging to bioprint a hydrogel-based three-dimensional vasculature-like structure in a single step. In this paper, we report a new hydrogel-based composite that offers impressive printability, shape integrity, and biocompatibility for 3D bioprinting of a per ...[more]

PMID: 29203812

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