A quantitative hypermorphic CNGC allele confers ectopic calcium flux and impairs cellular development.

ABSTRACT: The coordinated control of Ca²⁺ signaling is essential for development in eukaryotes. Cyclic nucleotide-gated channel (CNGC) family members mediate Ca²⁺ influx from cellular stores in plants (Charpentier et al., 2016; Gao et al., 2016; Frietsch et al., 2007; Urquhart et al., 2007). Here, we report the unusual genetic behavior of a quantitative gain-of-function CNGC mutation (brush) in Lotus japonicus resulting in a leaky tetrameric channel. brush resides in a cluster of redundant CNGCs encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in assembly and gating properties. The recessive mongenic brush mutation impaired root development and infection by nitrogen-fixing rhizobia. The brush a

SUBMITTER: Chiasson DM 

PROVIDER: S-EPMC5716663 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature