Emergence of Resistance Mutations in Salmonella enterica Serovar Typhi Against Fluoroquinolones.

ABSTRACT:

Background

Little is known about the evolutionary process and emergence time of resistance mutations to fluoroquinolone in Salmonella enterica serovar Typhi.

Methods

We analyzed S. Typhi isolates collected from returned travelers between 2001 and 2016. Based on ciprofloxacin susceptibility, isolates were categorized as highly resistant (minimum inhibitory concentration [MIC] ≥ 4 μg/mL [CIP^HR]), resistant (MIC = 1-2 μg/mL [CIP^R]), intermediate susceptible (MIC = 0.12-0.5 μg/mL [CIP^I]), and susceptible (MIC ≤ 0.06 μg/mL [CIP^S]).

Results

A total of 107 isolates (33 CIP^HR, 14 CIP^R, 30 CIP^I, and 30 CIP^S) were analyzed by whole-genome sequencing; 2461 single nucleotide poly

SUBMITTER: Matono T 

PROVIDER: S-EPMC5726467 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature