Race/ethnicity difference in the pharmacogenetics of bilirubin-related atazanavir discontinuation.

ABSTRACT:

Background

Atazanavir causes plasma indirect bilirubin to increase. We evaluated associations between Gilbert's polymorphism and bilirubin-related atazanavir discontinuation stratified by race/ethnicity.

Patients and methods

Patients had initiated atazanavir/ritonavir-containing regimens at an HIV primary care clinic in the southeastern USA, and had at least 12 months of follow-up data. Metabolizer group was defined by UGT1A1 rs887829 C→T. Genome-wide genotype data were used to adjust for genetic ancestry in combined population analyses.

Results

Among 321 evaluable patients, 15 (4.6%) had bilirubin-related atazanavir discontinuation within 12 months. Homozygosity for rs887829 T/T was present in 28.1% of Black, 21.4% of Hispanic, and 8.6% of White patients. Among all p

SUBMITTER: Leger P 

PROVIDER: S-EPMC5726942 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature