Dataset Information

Prognostic value and molecular correlates of a CT image-based quantitative pleural contact index in early stage NSCLC.

ABSTRACT:

Purpose

To evaluate the prognostic value and molecular basis of a CT-derived pleural contact index (PCI) in early stage non-small cell lung cancer (NSCLC).

Experimental design

We retrospectively analysed seven NSCLC cohorts. A quantitative PCI was defined on CT as the length of tumour-pleura interface normalised by tumour diameter. We evaluated the prognostic value of PCI in a discovery cohort (n = 117) and tested in an external cohort (n = 88) of stage I NSCLC. Additionally, we identified the molecular correlates and built a gene expression-based surrogate of PCI using another cohort of 89 patients. To further evaluate the prognostic relevance, we used four datasets totalling 775 stage I patients with publically available gene expression data and linked survival information.

Results

At a cutoff of 0.8, PCI stratified patients for overall survival in both imaging cohorts (log-rank p = 0.0076, 0.0304). Extracellular matrix (ECM) remodelling was enriched among genes associated with PCI (p = 0.0003). The genomic surrogate of PCI remained an independent predictor of overall survival in the gene expression cohorts (hazard ratio: 1.46, p = 0.0007) adjusting for age, gender, and tumour stage.

Conclusions

CT-derived pleural contact index is associated with ECM remodelling and may serve as a noninvasive prognostic marker in early stage NSCLC.

Key points

• A quantitative pleural contact index (PCI) predicts survival in early stage NSCLC. • PCI is associated with extracellular matrix organisation and collagen catabolic process. • A multi-gene surrogate of PCI is an independent predictor of survival. • PCI can be used to noninvasively identify patients with poor prognosis.

SUBMITTER: Lee J

PROVIDER: S-EPMC5741526 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Publications

Prognostic value and molecular correlates of a CT image-based quantitative pleural contact index in early stage NSCLC.

Lee Juheon J Cui Yi Y Sun Xiaoli X Li Bailiang B Wu Jia J Li Dengwang D Gensheimer Michael F MF Loo Billy W BW Diehn Maximilian M Li Ruijiang R

European radiology 20170807 2

<h4>Purpose</h4>To evaluate the prognostic value and molecular basis of a CT-derived pleural contact index (PCI) in early stage non-small cell lung cancer (NSCLC).<h4>Experimental design</h4>We retrospectively analysed seven NSCLC cohorts. A quantitative PCI was defined on CT as the length of tumour-pleura interface normalised by tumour diameter. We evaluated the prognostic value of PCI in a discovery cohort (n = 117) and tested in an external cohort (n = 88) of stage I NSCLC. Additionally, we i ...[more]

PMID: 28786009

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Dataset Information

Prognostic value and molecular correlates of a CT image-based quantitative pleural contact index in early stage NSCLC.

Purpose

Experimental design

Results

Conclusions

Key points

Publications

Prognostic value and molecular correlates of a CT image-based quantitative pleural contact index in early stage NSCLC.

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