Prognostic value and molecular correlates of a CT image-based quantitative pleural contact index in early stage NSCLC.

ABSTRACT:

Purpose

To evaluate the prognostic value and molecular basis of a CT-derived pleural contact index (PCI) in early stage non-small cell lung cancer (NSCLC).

Experimental design

We retrospectively analysed seven NSCLC cohorts. A quantitative PCI was defined on CT as the length of tumour-pleura interface normalised by tumour diameter. We evaluated the prognostic value of PCI in a discovery cohort (n = 117) and tested in an external cohort (n = 88) of stage I NSCLC. Additionally, we identified the molecular correlates and built a gene expression-based surrogate of PCI using another cohort of 89 patients. To further evaluate the prognostic relevance, we used four datasets totalling 775 stage I patients with publically available gene expression data and linked survival information

SUBMITTER: Lee J 

PROVIDER: S-EPMC5741526 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature