AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection.

ABSTRACT: Enhancer elements are genomic regulatory sequences that direct the selective expression of genes so that genetically identical cells can differentiate and acquire the highly specialized forms and functions required to build a functioning animal. To differentiate, cells must select from among the ∼10⁶ enhancers encoded in the genome the thousands of enhancers that drive the gene programs that impart their distinct features. We used a genetic approach to identify transcription factors (TFs) required for enhancer selection in fibroblasts. This revealed that the broadly expressed, growth-factor-inducible TFs FOS/JUN (AP-1) play a central role in enhancer selection. FOS/JUN selects enhancers together with cell-type-specific TFs by collaboratively binding to nucleosomal enhancers and

SUBMITTER: Vierbuchen T 

PROVIDER: S-EPMC5744881 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature