Group analysis identifies differentially elevated biomarkers with distinct outcomes for advanced acute kidney injury in cardiac surgery.

ABSTRACT:

Aim

To investigate early postoperative biomarkers for risk discrimination of advanced acute kidney injury (AKI).

Materials & methods

Postoperative plasma biomarkers including NGAL, h-FABP, CK-MB, hsTNT, NT-proBNP, IL-6, IL-10 and VEGF were analyzed using group-based method among 426 patients with AKI after cardiac surgery.

Results

Six patient groups with distinct biomarker patterns were identified. Individual biomarker displayed significant difference across the groups. The groups showed better discrimination for advanced AKI than any single biomarker either with or without adjusting for clinical variables. Average concentration of a single biomarker within each group, mortality and risk of a secondary outcome all demonstrated an approximately U-shaped relationship wi

SUBMITTER: Lin H 

PROVIDER: S-EPMC5753615 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature