Characterizing Helicobacter pylori cagA in Myanmar.

ABSTRACT:

Background/aims

Differences in the Helicobacter pylori infection rate are not sufficient to clarify the dissimilarity of gastric cancer incidence between Myanmar and its neighboring countries. To better understand this trend, the H. pylori virulence gene cagA was characterized in Myanmar.

Methods

Glutamate-proline-isoleucine-tyrosine-alanine (EPIYA) patterns and CagA multimerization (CM) motifs of cagA genotypes were examined by performing polymerase chain reactions and DNA sequencing.

Results

Of 69 tested H. pylori strains, cagA-positive patients had significantly more severe histological scores in their antrum than cagA-negative patients. Sequence analysis revealed that 94.1% of strains had Western-type cagA co

SUBMITTER: Myint T 

PROVIDER: S-EPMC5753684 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature