Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis.

ABSTRACT:

Background

The association between dilated cardiomyopathy (DCM) and low thyroid hormone (TH) levels has been previously described. In these patients abnormal thyroid function is significantly related to impaired left ventricular (LV) function and increased risk of death. Although TH was originally thought to be produced exclusively by the thyroid gland, we recently reported TH biosynthesis in the human ischemic heart.

Objectives

Based on these findings, we evaluated whether the genes required for TH production are also altered in patients with DCM.

Methods

Twenty-three LV tissue samples were obtained from patients with DCM (n = 13) undergoing heart transplantation and control donors (n = 10), and used for RNA sequencing analysis. The number of LV DCM samples was incre

SUBMITTER: Gil-Cayuela C 

PROVIDER: S-EPMC5761948 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature