Nephrin Loss Can Be Used to Predict Remission and Long-term Renal Outcome in Patients With Minimal Change Disease.

ABSTRACT:

Introduction

Minimal change disease is a common cause of nephrotic syndrome. In general, patients with minimal change disease respond to corticosteroids and have excellent long-term renal survival. However, some patients have less favorable outcome. These patients are often thought to have progressed to focal segmental glomerulosclerosis. We previously reported that a segmental loss of podocyte markers is present before the development of focal segmental glomerulosclerosis in a rat model. Here, we investigated whether loss of podocyte marker nephrin can serve as a biomarker for predicting poor outcome in patients with minimal change disease.

Methods

We obtained 47 kidney biopsy samples from patients diagnosed with minimal change disease and stained sections with periodic aci

SUBMITTER: van de Lest NA 

PROVIDER: S-EPMC5762955 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature