Depression is Associated with CRP SNPs in Patients with Family History.

ABSTRACT:

Objective

The pathogenesis of depression is not fully understood, but studies have suggested that higher circulating levels of C reactive protein (CRP) might relate to depression occurrence. However, due to the highly variability of individual patients' conditions, the results to date are inconsistent. Considering Single nucleotide polymorphisms (SNPs) of CRP gene have also been suggested to predict plasma CRP levels. In the present study, we hypothesize that inherited CRP allelic variations may co-vary with depressive symptomatology.

Methods

We recruited patients with a diagnosis of depression, with or without family depression history. We then detected serum CRP levels, as well as genome CRP SNPs from participants of this project.

Results

We found a significantly hi

SUBMITTER: Yibulaiyin H 

PROVIDER: S-EPMC5765705 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature