Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer.
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ABSTRACT: Background
Breast cancer is the most common cancer in women worldwide. Cancer-secreted exosomes have recently been recognized as important mediators of intercellular communication. The aim of this study was to determine the role of exosomal long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in breast cancer progression.Materials and methods
Breast cancer specimens were obtained with informed consent from patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect MALAT1 expression, and cellular proliferation was measured using cell counting kit-8 (CCK-8) assay.Results
MALAT1 was highly expressed in breast cancer tissues and associated with disease progression. Breast cancer exosomes promoted cell proliferation and exosome-mediated MALAT1 to induce cell proliferation.Conclusion
These findings indicated that exosomal MALAT1 could regulate cancer progression and represent a novel strategy for overcoming breast cancer.
SUBMITTER: Zhang P
PROVIDER: S-EPMC5767090 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer.
Zhang Ping P Zhou Hongxing H Lu Kefeng K Lu Yunou Y Wang Yan Y Feng Tongbao T
OncoTargets and therapy 20180109
<h4>Background</h4>Breast cancer is the most common cancer in women worldwide. Cancer-secreted exosomes have recently been recognized as important mediators of intercellular communication. The aim of this study was to determine the role of exosomal long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in breast cancer progression.<h4>Materials and methods</h4>Breast cancer specimens were obtained with informed consent from patients. Quantitative real-time polymerase ...[more]
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