Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer.

ABSTRACT:

Background

Breast cancer is the most common cancer in women worldwide. Cancer-secreted exosomes have recently been recognized as important mediators of intercellular communication. The aim of this study was to determine the role of exosomal long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in breast cancer progression.

Materials and methods

Breast cancer specimens were obtained with informed consent from patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect MALAT1 expression, and cellular proliferation was measured using cell counting kit-8 (CCK-8) assay.

Results

MALAT1 was highly expressed in breast cancer tissues and associated with disease progression. Breast cancer exosomes promoted cell proliferat

SUBMITTER: Zhang P 

PROVIDER: S-EPMC5767090 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature