Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy.

ABSTRACT: A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer the

SUBMITTER: Qiu M 

PROVIDER: S-EPMC5776980 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature