Development and validation of a priori risk model for extensive white matter lesions in people age 65 years or older: the Dijon MRI study.

ABSTRACT:

Objectives

The objective was to develop and validate a risk model for the likelihood of extensive white matter lesions (extWML) to inform clinicians on whether to proceed with or forgo diagnostic MRI.

Design

Population-based cohort study and multivariable prediction model.

Setting

Two representative samples from France.

Participants

Persons aged 60-80 years without dementia or stroke. Derivation sample n=1714; validation sample n=789.

Primary and secondary outcome measures

Volume of extWML (log cm³) was obtained from T2-weighted images in a 1.5 T scanner. 20 candidate risk factors for extWML were evaluated with the C-statistic. Secondary outcomes in validation included incident stroke over 12 years follow-up.

Results

The multivariable p

SUBMITTER: Tully PJ 

PROVIDER: S-EPMC5778304 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature