Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment.

ABSTRACT: Ovarian cancer is characterized by early transcoelomic metastatic spread via the peritoneal fluid, where tumor cell spheroids (TU), tumor-associated T cells (TAT), and macrophages (TAM) create a unique microenvironment promoting cancer progression, chemoresistance, and immunosuppression. However, the underlying signaling mechanisms remain largely obscure. To chart these signaling networks, we performed comprehensive proteomic and transcriptomic analyses of TU, TAT, and TAM from ascites of ovarian cancer patients. We identify multiple intercellular signaling pathways driven by protein or lipid mediators that are associated with clinical outcome. Beyond cytokines, chemokines and growth factors, these include proteins of the extracellular matrix, immune checkpoint regulators, complement facto

SUBMITTER: Worzfeld T 

PROVIDER: S-EPMC5795391 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature