Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses.

ABSTRACT: Human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV), two members of the Pneumoviridae family, account for the majority of severe lower respiratory tract infections worldwide in very young children. They are also a frequent cause of morbidity and mortality in the elderly and immunocompromised adults. High levels of neutralizing antibodies, mostly directed against the viral fusion (F) glycoprotein, correlate with protection against either hRSV or hMPV However, no cross-neutralization is observed in polyclonal antibody responses raised after virus infection or immunization with purified F proteins. Based on crystal structures of hRSV F and hMPV F, we designed chimeric F proteins in which certain residues of well-characterized antigenic sites were swapped between t

SUBMITTER: Olmedillas E 

PROVIDER: S-EPMC5801496 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature