Ontology highlight
ABSTRACT:
SUBMITTER: Collopy LC
PROVIDER: S-EPMC5805788 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180208 1
Understanding the intricacies of telomerase regulation is crucial due to the potential health benefits of modifying its activity. Telomerase is composed of an RNA component and reverse transcriptase. However, additional factors required during biogenesis vary between species. Here we have identified fission yeast Lar7 as a member of the conserved LARP7 family, which includes the Tetrahymena telomerase-binding protein p65 and human LARP7. We show that Lar7 has conserved RNA-recognition motifs, wh ...[more]