Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162.

ABSTRACT: Staphylococcus aureus is a major cause of nosocomial infections and secretes a diverse spectrum of virulence determinants as well as forms biofilm. The emergence of antibiotic-resistant S. aureus highlights the need for alternative forms of therapeutics other than conventional antibiotics. One route to meet this need is screening small molecule derivatives for potential anti-infective activity. Using a previously optimized C. elegans - S. aureus small molecule screen, we identified a benzimidazole derivative, UM-C162, which rescued nematodes from a S. aureus infection. UM-C162 prevented the formation of biofilm in a dose-dependent manner without interfering with bacterial viability. To examine the effect of UM-C162 on the expression of S. aureus virulence genes, a genome-wide transcriptome

SUBMITTER: Kong C 

PROVIDER: S-EPMC5807447 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature