Dataset Information

Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett's esophagus.

ABSTRACT:

Background

The association of alcohol intake with the incidence of Barrett's esophagus (BE) has been inconsistent. Although hiatal hernia and male sex are well-known risk factors of BE, its effect on the association of alcohol intake with the incidence of BE remains unknown.

Aim

To investigate whether the influence of alcohol intake on the occurrence of BE might differ depending on male sex and presence of hiatal hernia.

Methods

We utilized a database of 8031 patients that underwent upper endoscopy for health screening in a prospective, multicenter, cohort study (the Upper Gastro Intestinal Disease study). The incidence of endoscopic columnar-lined esophagus (eCLE; endoscopically diagnosed BE) was the outcome variable. Multivariable logistic regression analysis was conducted to assess the association between alcohol intake and eCLE stratified by male sex and hiatal hernia, adjusting for clinical features and other potential confounders.

Results

Alcohol intake (≥20 g/day) showed a marginally significant association with the incidence of eCLE in participants without hiatal hernia (0 vs. ≥20 g/day; odds ratio [OR], 1.62; 95% confidence interval [CI], 0.92-2.85, P = 0.09) but not in participants with hiatal hernia (0 vs. ≥20/day; OR, 0.99; 95% CI, 0.59-1.65; P = 0.95). Furthermore, alcohol intake (≥20 g/day) was significantly associated with the incidence of eCLE in male participants without hiatal hernia (0 vs. ≥20 g/day; OR, 1.98; 95% CI, 1.04-4.03; P = 0.04) but not in female participants without hiatal hernia (0 vs. ≥20 g/day; OR, 0.47; 95% CI, 0.03-2.37; P = 0.42).

Conclusions

The effect of alcohol intake on the incidence of eCLE might be associated with hiatal hernia status and male sex.

SUBMITTER: Masuda A

PROVIDER: S-EPMC5814023 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett's esophagus.

Masuda Atsuhiro A Fujita Tsuyoshi T Murakami Manabu M Yamazaki Yukinao Y Kobayashi Masao M Terao Shuichi S Sanuki Tsuyoshi T Okada Akihiko A Adachi Masayasu M Shiomi Hideyuki H Arisaka Yoshifumi Y Kutsumi Hiromu H Umegaki Eiji E Azuma Takeshi T

PloS one 20180215 2

<h4>Background</h4>The association of alcohol intake with the incidence of Barrett's esophagus (BE) has been inconsistent. Although hiatal hernia and male sex are well-known risk factors of BE, its effect on the association of alcohol intake with the incidence of BE remains unknown.<h4>Aim</h4>To investigate whether the influence of alcohol intake on the occurrence of BE might differ depending on male sex and presence of hiatal hernia.<h4>Methods</h4>We utilized a database of 8031 patients that ...[more]

PMID: 29447244

Similar Datasets

Project description:BackgroundBarrett's esophagus (BE) is a precursor of esophageal adenocarcinoma. It is critical to recognize the risk factors associated with BE.ObjectivesThe present meta-analysis aims to systematically estimate the association of hiatal hernia with the risk of BE.DesignA meta-analysis with trial sequential analysis.Data sources and methodsThe PubMed, EMBASE, and Cochrane Library databases were searched. The pooled odds ratios (ORs) and adjusted ORs (aORs) with their 95% confidence intervals (CIs) were calculated for the combined estimation of unadjusted data and data adjusted for confounders, respectively. Heterogeneity was quantified using the Cochrane Q test and I² statistics. Subgroup, meta-regression, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity.ResultsForty-seven studies with 131,517 participants were included. Based on the unadjusted data from 47 studies, hiatal hernia was significantly associated with an increased risk of any length BE (OR = 3.91, 95% CI = 3.31-4.62, p < 0.001). The heterogeneity was significant (I² = 77%; p < 0.001) and the definition of controls (p = 0.014) might be a potential contributor to heterogeneity. Based on the adjusted data from 14 studies, this positive association remained (aOR = 3.26, 95% CI = 2.44-4.35, p < 0.001). The heterogeneity was also significant (I² = 65%; p < 0.001). Meta-analysis of seven studies demonstrated that hiatal hernia was significantly associated with an increased risk of long-segment BE (LSBE) (OR = 10.01, 95% CI = 4.16-24.06, p < 0.001). The heterogeneity was significant (I² = 78%; p < 0.001). Meta-analysis of seven studies also demonstrated that hiatal hernia was significantly associated with an increased risk of short-segment BE (OR = 2.76, 95% CI = 2.05-3.71, p < 0.001). The heterogeneity was not significant (I² = 30%; p = 0.201).ConclusionHiatal hernia should be a significant risk factor for BE, especially LSBE.RegistrationPROSPERO registration number CRD42022367376.

Dataset Information

Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett's esophagus.

Background

Aim

Methods

Results

Conclusions

Publications

Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett's esophagus.

Similar Datasets

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