MiR miR on the wall, who's the most malignant medulloblastoma miR of them all?

ABSTRACT: microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated in cancer. There has been a large body of research on the role of miRNAs in medulloblastoma, the most common malignant brain tumor of childhood. The identification of the 4 molecular subgroups with distinct biological, genetic, and transcriptional features has revolutionized the field of medulloblastoma research over the past 5 years. Despite this, the growing body of research on miRNAs in medulloblastoma has largely focused on the clinical entity of a single disease rather than the molecular subgroups. This review begins by highlighting the role of miRNAs in development and progresses to explore thei

SUBMITTER: Wang X 

PROVIDER: S-EPMC5817951 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature