The role of calgranulin B gene on the biological behavior of squamous cervical cancer in vitro and in vivo.

ABSTRACT:

Objective

The objective of the study was to explore the role of calgranulin B gene on the biological behavior of squamous cervical cancer.

Methods

Differential transcription in calgranulin B gene between human papillomavirus (HPV)-positive and negative cervical cancer groups was identified, and the relationship between calgranulin B gene and matrix metalloproteinase (MMP) genes were explored using The Cancer Genome Atlas database. Subsequently, the role of calgranulin B on the cell proliferation, apoptosis, invasion and migration was investigated, through overexpression and/or underexpression of calgranulin B in cervical cancer cells. In addition, the effect of calgranulin B on the growth of the cervical cancer was studied via constructing

SUBMITTER: Zhang W 

PROVIDER: S-EPMC5818869 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature