Association Between Genomic Metrics and Immune Infiltration in Triple-Negative Breast Cancer.

ABSTRACT:

Importance

Why some triple-negative breast cancers (TNBCs) have high and others have low immune cell infiltration is unknown. Understanding how immune surveillance shapes the cancer genome could help in the selection of patients and the development of more effective immunotherapy strategies.

Objective

To examine the association between genomic metrics and the extent of immune infiltration in TNBCs.

Design, setting, and participants

This study, performed from June 1, 2015, through January 31, 2017, used DNA and RNA sequencing data and messenger RNA expression results from The Cancer Genome Atlas (TCGA) breast cancer data set (n = 1215) to calculate previously described immune metagene expression values and histologic lymphocyte counts to quantify immune infiltration an

SUBMITTER: Karn T 

PROVIDER: S-EPMC5824276 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature