Impact of seasonal influenza vaccination in the presence of vaccine interference.

ABSTRACT:

Background

Annual influenza vaccination is a key to preventing widespread influenza infections. Recent reports of influenza vaccine effectiveness (VE) indicate that vaccination in prior years may reduce VE in the current season, suggesting vaccine interference. The purpose of this study is to evaluate the potential effect of repeat influenza vaccinations in the presence of vaccine interference.

Methods

Using literature-based parameters, an age-structured influenza equation-based transmission model was used to determine the optimal vaccination strategy, while considering the effect of varying levels of interference.

Results

The model shows that, even in the presence of vaccine interference, revaccination reduces the influenza attack rate and provides individual benefit

SUBMITTER: Shim E 

PROVIDER: S-EPMC5825190 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature