P4HA1: A single-gene surrogate of hypoxia signatures in oral squamous cell carcinoma patients.

ABSTRACT:

Background and purpose

Hypoxia gene expression signatures are of high prognostic value for head and neck cancer patients. Recently, the prognostic information of a multiple-gene hypoxia signature was found to be provided by the mRNA level of P4HA1 alone (Tawk et al., 2016). Therefore, we studied the prognostic value of P4HA1 in an independent cohort of oral squamous cell carcinoma (OSCC) patients.

Material and methods

Frozen tumor samples of 118 adult OSCC patients were analysed for P4HA1 mRNA level by quantitative real-time TaqMan™ PCR analysis. Kaplan-Meier analysis and Cox's regression analysis were performed to characterize the prognostic impact of P4HA1 mRNA level in OSCC patients.

Results

The analyzed patient cohort was divided into f

SUBMITTER: Kappler M 

PROVIDER: S-EPMC5833914 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature