Exploring spatially adjacent TFBS-clustered regions with Hi-C data.

ABSTRACT:

Motivation

Transcription factor binding sites (TFBSs) are clustered in the human genome, forming the TFBS-clustered regions that regulate gene transcription, which requires dynamic chromatin configurations between promoters and distal regulatory elements. Here, we propose a regulatory model called spatially adjacent TFBS-clustered regions (SATs), in which TFBS-clustered regions are connected by spatial proximity as identified by high-resolution Hi-C data.

Results

TFBS-clustered regions forming SATs appeared less frequently in gene promoters than did isolated TFBS-clustered regions, whereas SATs as a whole appeared more frequently. These observations indicate that multiple distal TFBS-clustered regions combined to form SATs to regulate genes. Further examination confirmed tha

SUBMITTER: Chen H 

PROVIDER: S-EPMC5860062 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature