Assessment of disturbed glucose metabolism and surrogate measures of insulin sensitivity in obese children and adolescents.

ABSTRACT:

Background

With the rising prevalence of obesity and type 2 diabetes (T2D) in obese children, it is becoming imperative to detect disturbed glucose metabolism as early as possible in order to prevent T2D development.

Subjects/methods

Cross-sectional study of 92 obese children (median age 11.7 years, 51% female) and 7 lean children (median age 11.4 years, 57% female) who underwent an oral glucose tolerance test (OGTT) in a tertiary pediatric care center. Glucose tolerance was assessed and different indices for β-cell function, insulin sensitivity and insulin secretion were calculated.

Results

Nineteen obese children were identified with prediabetes (PD, 12 impaired glucose tolerance, 4 increased fasting glucose and 3 combined). Compared with the 73 obese children with

SUBMITTER: Roth CL 

PROVIDER: S-EPMC5865547 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature