Ontology highlight
ABSTRACT:
SUBMITTER: Turecek J
PROVIDER: S-EPMC5870134 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Cell reports 20161201 12
The output of the cerebellar cortex is conveyed to the deep cerebellar nuclei (DCN) by Purkinje cells (PCs). Here, we characterize the properties of the PC-DCN synapse in juvenile and adult mice and find that prolonged high-frequency stimulation leads to steady-state responses that become increasingly frequency independent within the physiological firing range of PCs in older animals, resulting in a linear relationship between charge transfer and activation frequency. We used a low-affinity anta ...[more]