Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study.

ABSTRACT:

Objective

To compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction.

Design

Cohort study using a healthcare database.

Setting

Nationwide sample of patient data from more than 700 hospitals across the United States.

Participants

6578 medical patients aged more than 18 years who initiated oral haloperidol or oral atypical antipsychotics (olanzapine, quetiapine, risperidone) during a hospital admission with a primary diagnosis of acute myocardial infarction between 2003 and 2014.

Main outcome measure

In-hospital mortality during seven days of follow-up from treatment initiation.

Results

Among 6578 patients (mean age 75.2 years) treat

SUBMITTER: Park Y 

PROVIDER: S-EPMC5871903 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature