Ontology highlight
ABSTRACT:
SUBMITTER: Kim K
PROVIDER: S-EPMC5884729 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cell metabolism 20180322 4
Excess plasma triglycerides (TGs) are a key component of obesity-induced metabolic syndrome. We have shown that γ-secretase inhibitor (GSI) treatment improves glucose tolerance due to inhibition of hepatic Notch signaling but found additional Notch-independent reduction of plasma TG-rich lipoproteins (TRLs) in GSI-treated, as well as hepatocyte-specific, γ-secretase knockout (L-Ncst) mice, which suggested a primary effect on hepatocyte TRL uptake. Indeed, we found increased VLDL and LDL particle ...[more]