Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids.

ABSTRACT: By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prep

SUBMITTER: Moodie LWK 

PROVIDER: S-EPMC5889410 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature