Ontology highlight
ABSTRACT:
SUBMITTER: Guo J
PROVIDER: S-EPMC5889661 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20180319 14
<i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A), the most abundant chemical modification in eukaryotic mRNA, has been implicated in <i>Drosophila</i> sex determination by modifying <i>Sex-lethal</i> (<i>Sxl</i>) pre-mRNA and facilitating its alternative splicing. Here, we identify a sex determination gene, <i>CG7358</i>, and rename it <i>xio</i> according to its loss-of-function female-to-male transformation phenotype. <i>xio</i> encodes a conserved ubiquitous nuclear protein of unknown fu ...[more]